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JNK1+2+3 Polyclonal Antibody, PE Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Mouse
  • Rat
  • Pig
  • Chicken

Predicted Reactivity

  • Dog
  • Cow
Overview
Catalog # bs-2592R-PE
Product Name JNK1+2+3 Polyclonal Antibody, PE Conjugated
Applications WB, FCM
Reactivity Human, Mouse, Rat, Pig, Chicken
Predicted Reactivity Dog, Cow
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse JNK1/2/3
Immunogen Range 151-250/384
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 2.64E+14
Swiss Prot Q61831
Subcellular location Cytoplasm, Nucleus
Synonyms JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); C238H4Rik; JNK; JNK1; Prkm8; SAPK1; AI849689; JNK2; Prkm9; AI85183; p54aSAPK; Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; MAP kinase p49 3F12; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; Mapk1; Prkm1
Background Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Application Dilution
WB 1:300-5000
FCM 1:20-100