Overview |
bsm-58003R |
PD-L1 (6C8) Monoclonal Antibody |
WB, FCM |
Human |
Specifications |
Unconjugated |
Rabbit |
Recombinant human PD-L1 extracellular domain |
Monoclonal |
6C8 |
IgG |
Not Determined |
Purified by Protein A. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
29126 |
Q9NZQ7 |
Programmed cell death 1 ligand 1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1; Programmed death ligand 1 |
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). |
Application Dilution |
WB |
1:300-5000 |
FCM |
1:20-100 |