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MUC1 (M5C7) Monoclonal Antibody

Applications

  • WB
  • ELISA
  • IHC-P

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-51126M
Product Name MUC1 (M5C7) Monoclonal Antibody
Applications WB, ELISA, IHC-P
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Mouse
Source Purified His-tagged MUC1 protein(Fragment) was used to produced this monoclonal antibody.
Clonality Monoclonal
Clone # M5C7
Isotype IgG2b
Concentration 0.5ug/ul
Purification Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 4582
Swiss Prot P15941
Synonyms EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; Mucin-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; Carcinoma-associated mucin; Episialin; Krebs von den Lungen-6; Peanut-reactive urinary mucin; Polymorphic epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin; MUC1
Background The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400