Overview |
bs-2636R-PE-Cy3 |
Integrin alpha 2b Polyclonal Antibody, PE-Cy3 Conjugated |
WB, FCM |
Human, Rat |
Mouse, Cow, Horse, Rabbit |
Specifications |
PE-Cy3 |
Rabbit |
KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b |
351-450/1033 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
16399 |
Q9QUM0 |
Cell membrane |
CD41; CD41B; GpIIb; AI172977; alphaIIb; Integrin alpha-IIb; GPalpha IIb; Platelet membrane glycoprotein IIb; Itga2b |
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Application Dilution |
WB |
1:300-5000 |
FCM |
1:20-100 |