| Overview |
| bs-11842R-PE-Cy3 |
| Frizzled 9/CD349 Polyclonal Antibody, PE-Cy3 Conjugated |
| WB |
| This antibody may have slight cross reactivity with Frizzled 10. |
| Human |
| Mouse, Rat |
| Specifications |
| PE-Cy3 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Frizzled 9/CD349 |
| 185-270/591 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 8326 |
| O00144 |
| Cell membrane |
| FZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9 |
| Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Application Dilution |
| WB |
1:500-2000 |
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