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COBRA1 (NELF-B) Antibody

Applications

  • WB

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-70044M
Product Name COBRA1 (NELF-B) Antibody
Applications WB
Specificity Specific for endogenous levels of the ~62 kDa COBRA1 protein.
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Mouse
Source Recombinant full length human COBRA1 purified from E. coli.
Clonality Monoclonal
Clone # F7E4
Isotype IgG1
Concentration Lot Dependent
Purification Purified by Protein G.
Storage Buffer PBS + 0.05% NaN3
Storage Condition Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Target
Gene ID 25920
Swiss Prot Q8WX92
Synonyms A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody
Background COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)
Application Dilution
WB 1:300-5000