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Integrin beta 4 (6C1) Monoclonal Antibody

Applications

  • WB
  • IHC-P
  • IHC

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-52927R
Product Name Integrin beta 4 (6C1) Monoclonal Antibody
Applications WB, IHC-P, IHC
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Rabbit
Source Human Integrin beta 4 between 1750-1850 amino acids
Clonality Monoclonal
Clone # 6C1
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Swiss Prot P16144
Synonyms Integrin beta-4, GP150, CD104, ITGB4
Background Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IHC