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AR7

Overview
Catalog # bs-83130c-5-mg
Product Name AR7
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information Atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Description CAS Number: 80306-38-3

Chemical Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

Molecular weight: 257.72

Formula: C15H12ClNO

Solubility: DMSO (30 mg/ml)

Physical Properties: Pale pink solid

Purity: 98% by TLC NMR (Conforms)