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ABT-869

Overview
Catalog # bs-83107c-5-mg
Product Name ABT-869
Specifications
Storage Buffer Colorless to pale yellow liquid
Storage Condition -20°C
Target
Product Information ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5
Description CAS Number: 796967-16-3

Chemical Name: 1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea

Molecular weight: 375.41

Formula: C21H18FN5O

Solubility: DMSO (30 mg/ml)

Physical Properties: Off-white solid

Purity: >98% by HPLC NMR (Conforms)