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Acalabrutinib

Overview
Catalog # bs-83027c-5-mg
Product Name Acalabrutinib
Specifications
Storage Buffer Yellow solid
Storage Condition -20°C
Target
Product Information Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib.2 Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.3 Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.4
Description CAS Number: 1420477-60-6

Chemical Name: 4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide

Molecular weight: 465.52

Formula: C26H23N7O2

Solubility: DMSO (>25 mg/ml)

Physical Properties: Yellow solid

Purity: 98% by HPLC NMR (Conforms)