ABT-737
Overview | |
Catalog # | bs-82700c-5-mg |
Product Name | ABT-737 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4 |
Description | CAS Number: 852808-04-9 Chemical Name: 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide Molecular weight: 813.43 Formula: C42H45ClN6O5S2 Solubility: DMSO (5 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms) |