Verrucarin A
Overview | |
Catalog # | bs-82691c-1-mg |
Product Name | Verrucarin A |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5 |
Description | CAS Number: 3148-09-2 Chemical Name: Molecular weight: 502.56 Formula: C27H34O9 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (conforms) |