Thiostrepton
Overview | |
Catalog # | bs-82393c-1-g |
Product Name | Thiostrepton |
Specifications | |
Storage Buffer | Yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | Novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2)1-2. Displays antitumor activity. Induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression3. |
Description | CAS Number: 1393-48-2 Chemical Name: Fermentation product from Streptomyces azureus Molecular weight: 1664.91 Formula: C72H85N19O18S5 Solubility: DMSO (15 mg/ml) Chloroform (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC and HPLC |