680C91
Overview | |
Catalog # | bs-82245c-5-mg |
Product Name | 680C91 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4. |
Description | CAS Number: 163239-22-3 Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole Molecular weight: 238.27 Formula: C15H11FN2 Solubility: DMSO (20 mg/ml) Ethanol (10 mg/ml) Physical Properties: Light brown solid Purity: 98% by TLC, NMR (Conforms) |