Xestospongin C
Overview | |
Catalog # | bs-82134c-10-ug |
Product Name | Xestospongin C |
Specifications | |
Storage Buffer | Yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM1. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling3. Cell permeable. |
Description | CAS Number: 88903-69-9 Chemical Name: Natural product isolated from the marine sponge Xestospongia sp. Molecular weight: 446.71 Formula: C28H50N2O2 Solubility: DMSO (10 mg/ml) Physical Properties: Lyophilized solid Purity: 97% by TLC NMR (Conforms) |