Zileuton
Overview | |
Catalog # | bs-82065c-10-mg |
Product Name | Zileuton |
Specifications | |
Storage Buffer | white solid |
Storage Condition | -20°C |
Target | |
Product Information | Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO). |
Description | CAS Number: 111406-87-2 Chemical Name: N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea Molecular weight: 236.29 Formula: C11H12N2O2S Solubility: DMSO (25 mg/ml) Physical Properties: white solid Purity: >98%, NMR (Conforms) |