Veliparib 2HCl (ABT-888)
Overview | |
Catalog # | bs-80508C |
Product Name | Veliparib 2HCl (ABT-888) |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:317.2 Formula:C13H16N4O • 2HCl Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 40 mg/ml). Chemical Name:2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride |
Description | PanPARP inhibitor (Ki = 5.2 PARP1 and 2.9 nM PARP2)1. Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells4. |