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15 Lipoxygenase 1 Polyclonal Antibody, PE-Cy7 Conjugated

Applications

  • FCM

Reactivity

  • Human
  • Mouse
  • Rat

Predicted Reactivity

  • Cow
  • Pig
Overview
Catalog # bs-6505R-PE-Cy7
Product Name 15 Lipoxygenase 1 Polyclonal Antibody, PE-Cy7 Conjugated
Applications FCM
Reactivity Human, Mouse, Rat
Predicted Reactivity Cow, Pig
Specifications
Conjugation PE-Cy7
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1
Immunogen Range 581-662/662
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 246
Swiss Prot P16050
Subcellular location Cytoplasm
Synonyms 12-LOX; 15LOX-1; 15-LOX-1; Arachidonate 15-lipoxygenase; 15-LOX; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate omega-6 lipoxygenase; ALOX15; LOG15
Background Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
Application Dilution
FCM 1:20-100