UNC0379 --- Lysine Methyltransferase SETD8 Inhibitor

Overview
Catalog #	bs-60207c-2-mg-solid
Product Name	UNC0379 --- Lysine Methyltransferase SETD8 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 413.56 Formula: C23 H35 N5 O2 CAS Number: 1620401-82-2 InChi Key: WEXCGGWTIDNVNT-UHFFFAOYSA-N InChi: InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26) Smiles: COC1C=C2N=C(N=C(NCCCCCN3CCCC3)C2=CC=1OC)N1CCCC1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response.