BLU-9931
| Overview | |
| Catalog # | bs-6481C |
| Product Name | BLU-9931 |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 509.38 Formula: C26 H22 Cl2 N4 O3 CAS Number: 1538604-68-0 InChi Key: TXEBNKKOLVBTFK-UHFFFAOYSA-N InChi: InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32) Smiles: CC1=CC=CC(NC(=O)C=C)=C1NC1=NC2=CC=C(C=C2C=N1)C1C(Cl)=C(C=C(OC)C=1Cl)OC Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years |
| Description | BLU-9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU-9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU-9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor. |
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