Overview |
bs-9022R-Cy3 |
IQCG Polyclonal Antibody, Cy3 Conjugated |
WB, IF(IHC-P) |
Human, Mouse, Rat |
Specifications |
Cy3 |
Rabbit |
KLH conjugated synthetic peptide derived from human IQCG |
301-400/443 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
84223 |
IQ domain containing protein G; IQ mot containing G; DKFZp434B227; FLJ11667; FLJ23571; FLJ37775; IQCG_HUMAN. |
IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn -helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid/myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and/or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events. |
Application Dilution |
WB |
1:300-5000 |
IF(IHC-P) |
1:50-200 |