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MLKL Recombinant Antibody

Paraformaldehyde-fixed and paraffin-embedded Human tonsil tissue incubated with MLKL (3G4) Monoclonal Antibody (bsm-52256R) at 1:100, overnight at 4\u00b0C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
Paraformaldehyde-fixed and paraffin-embedded Human tonsil tissue incubated with MLKL (3G4) Monoclonal Antibody (bsm-52256R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.

Applications

  • WB
  • IHC

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-52256r
Product Name MLKL Recombinant Antibody
Applications WB, IHC
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Rabbit
Source Human MLKL between 350 to C-terminus
Immunogen Range 350-471/471
Clonality Monoclonal
Isotype IgG
Concentration Lot dependent
Purification Purified by Protein A.
Storage Buffer 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 197259
Swiss Prot Q8NB16
Subcellular location Cell membrane
Synonyms Mixed lineage kinase domain-like protein, hMLKL; MLKL
Background Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Application Dilution
WB 1:300-5000
IHC

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