| Overview |
| bsm-52219m |
| PIK3R1 Monoclonal Antibody |
| WB, IHC-P, IHC-F, IF, ICC/IF |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Mouse |
| Recombinant human PI3-kinase p85 subunit alpha protein, around 600-700aa. |
| Monoclonal |
| 9B3 |
| IgG1 |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 5295 |
| P27986 |
| Phosphatidylinositol 3-kinase regulatory subunit alpha; PIK3R1; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PIK3R1; GRB1; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha |
| Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
| IF |
|
| ICC/IF |
1:50-100 |
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