Overview |
bsm-51265M |
PINK1 (8T5) Monoclonal Antibody |
WB, IHC-P |
Human |
Specifications |
Unconjugated |
Mouse |
Recombinant PINK1 protein was used to produced this monoclonal antibody. |
Monoclonal |
8T5 |
IgG1 |
0.5ug/ul |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
65018 |
Q9BXM7 |
BRPK; PARK6; Serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; PINK1 |
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |