mouse CD16/32 Rat

Applications

Reactivity

Mouse

Overview
Catalog #	bsm-30155a
Product Name	mouse CD16/32 Rat
Applications	FCM
Reactivity	Mouse
Specifications
Conjugation	Unconjugated
Host	Rat
Clonality	Monoclonal
Clone #	6G10
Isotype	Rat IgG2a, k
Concentration	1mg/ml
Purification	Purified by Protein G.
Storage Buffer	0.01M PBS (pH7.4).
Storage Condition	Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	14131
Swiss Prot	P08508
Subcellular location	Secreted, Cell membrane
Synonyms	CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; FcGRIIIA; IGFR3; IMD20; CD16-2; Fcgr4; FCG3A_HUMAN; FCGR3A; IgG Fc receptor III-A; CD16a antigen; Fc-gamma RIII-alpha (Fc-gamma RIII \| Fc-gamma RIIIa \| FcRIII \| FcRIIIa \| FcgammaRIIIA); IgG Fc receptor III-2; FCGR3_MOUSE; IgG Fc receptor III; Fc-gamma RIII (FcRIII); FCGR3_RAT; Fc gamma receptor IIIa; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG receptor IIIa; FcγR III;
Background	This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Application Dilution
FCM