Metformin HCl

Overview
Catalog #	bs-83305c-25g
Product Name	Metformin HCl
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK) pathway.1,2 Displays antiproliferative and pro-apoptotic actions in a variety of cancer cell lines.3,4 Induces autophagy via inhibition of the mTOR pathway. Activates PGC1 and improves mitochondrial dynamics in renal tubular cells.5 Upregulates SIRT1 activity in endothelial cells.6 Neuroprotective and lowers -synuclein phosphorylation in the Parkinson’s disease MPTP mouse model.7
Description	CAS Number: 1115-70-4 Chemical Name: Anti-diabetic agent Molecular Weight: 165.63 Formula: C4H11N5 · HCl Solubility: DMSO (8 mg/ml) Water (16 mg/ml Physical Properties: White solid Purity: 98%, NMR (Conforms)