J147 --- Neuroprotective Small Molecule
| Overview | |
| Catalog # | bs-60012c-10mg |
| Product Name | J147 --- Neuroprotective Small Molecule |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 350.33 Formula: C18 H17 F3 N2 O2 CAS Number: 1146963-51-0 InChi Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N InChi: InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+ Smiles: COC1C=C(/C=N/N(C(=O)C(F)(F)F)C2C=CC(C)=CC=2C)C=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | J147 is a potent and orally active neurotrophic molecule discovered based upon efficacy in multiple cellular models of age-associated pathologies rather than exclusively amyloid metabolism. J147 is broadly neuroprotective, and active in six different assays that represent distinct neurotoxicity pathways related to aging and neurodegenerative diseases, with EC50 between 10 and 200 nM. It can also improve memory in normal rodents, and prevent the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model. |