Recombinant SARS-COV-2 Spike S1 (N501Y, K417N, E484K) Protein

Overview
Catalog #	bs-46017P
Product Name	Recombinant SARS-COV-2 Spike S1 (N501Y, K417N, E484K) Protein
Applications	WB, ELISA, HPLC
Reactivity	SARS-CoV-2
Specifications
Conjugation	Unconjugated
Source	Recombinant SARS-COV-2 Spike S1 (N501Y, K417N, E484K) protein is expressed from mammalian with a His-tag at the C-terminal
Storage Buffer	Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	YP_009724390.1
Background	SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually in part due to amino acid substitutions on the SARS-CoV-2 Spike protein. The results of a study show the N501Y replacement in this region of the interface (present in both the UK and South African strains) should be favorable for the interaction with ACE2, while the K417N and E484K substitutions (South African strain) would seem neutral or even unfavorable.