Recombinan human ACE2 Protein, N-His

Overview
Catalog #	bs-41410P
Product Name	Recombinan human ACE2 Protein, N-His
Applications	WB, ELISA
Reactivity	Human
Specifications
Conjugation	Unconjugated
Source	An E.coli expression system produces recombinant Human ACE2 Protein, and the target gene encoding amino acids 243-369 is expressed with His Tag.
Storage Buffer	Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	NP_001358344.1
Background	Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the outer surface (cell membranes) of cells in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1‚Äì7) (a vasodilator). ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7) making it a promising drug target for treating cardiovascular diseases. ACE2 also serves as the entry point into cells for some coronaviruses including Severe acute respiratory syndrome coronavirus 2.