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Lyn (Tyr508) Polyclonal Antibody

Formalin-fixed and paraffin embedded human breast cancer labeled with Anti-Phospho-Lyn (Tyr507) Polyclonal Antibody, Unconjugated (bs-3256R) followed by conjugation to the secondary antibody and DAB staining\\n
Formalin-fixed and paraffin embedded human breast cancer labeled with Anti-Phospho-Lyn (Tyr507) Polyclonal Antibody, Unconjugated (bs-3256R) followed by conjugation to the secondary antibody and DAB staining\n

Applications

  • WB
  • IHC-P
  • IF(IHC-P)

Reactivity

  • Human
  • Mouse
  • Rat

Predicted Reactivity

  • Dog
  • Cow
  • Sheep
  • Horse
  • Chicken
  • Pig
  • Cat
  • Rabbit
  • Zebrafish
  • GuineaPig
Overview
Catalog # bs-3256r-100ul
Product Name Lyn (Tyr508) Polyclonal Antibody
Applications WB, IHC-P, IF(IHC-P)
Reactivity Human, Mouse, Rat
Predicted Reactivity Dog, Cow, Sheep, Horse, Chicken, Pig, Cat, Rabbit, Zebrafish, GuineaPig
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human Lyn around the phosphorylation site of Tyr508
Modification Site Tyr508
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 4067
Synonyms Lyn phospho Y508; Lyn phospho Tyr508; p-Lyn Tyr508; Hck 2; JTK 8; JTK8; ONCOGENE LYN; Tyrosine protein kinase LYN; V yes 1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral v yes 1 related oncogene homolog; AA407514; EC 2.7.10.2; FLJ26625; LYN_HUMAN.
Background Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

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