| Overview |
| bs-3174R-PE |
| Phospho-HDAC3 (Ser424) Polyclonal Antibody, PE Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Human, Mouse, Rat |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human HDAC3 around the phosphorylation site of Ser424 |
| Ser424 |
| Polyclonal |
| #REF! |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 8841 |
| Cytoplasm, Nucleus |
| HDAC3 phospho S424; HDAC3 phospho Ser424; p-HDAC3 Ser424; RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 HD3 RPD3-2; histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN. |
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
|
| IF(IHC-F) |
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| IF(ICC) |
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