| Overview |
| bs-3140R-BF647 |
| Phospho-FoxO3a (Ser253) Polyclonal Antibody, AbBy Fluor-647 Conjugated |
| WB, FCM, IF(IHC-P), IF(IHC-F), IF(ICC) |
| This phosphorylation site is homologous to Ser252 in Mouse and Rat. |
| Human, Mouse, Rat |
| Dog, Cow, Sheep, Pig, Horse, Chicken |
| Specifications |
| AbBy Fluor-647 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human FoxO3a around the phosphorylation site of Ser253 |
| Ser253 |
| Polyclonal |
| #REF! |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 2309 |
| O43524 |
| Cytoplasm, Nucleus |
| FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3 |
| Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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