PRELP Polyclonal Antibody
Applications
Predicted Reactivity
| Overview | |
| Catalog # | bs-13707R-100uL |
| Product Name | PRELP Polyclonal Antibody |
| Applications |
IHC-P
IHC-F
|
| Predicted Reactivity | Human, Mouse, Rat, Cow, Horse, Rabbit |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human PRELP |
| Immunogen Range | 151-250/382 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Subcellular location | Cytoplasm |
| Synonyms | 55 kDa leucine rich repeat protein of articular cartilage; MST161; MSTP161; Prelp; PRELP_HUMAN; Prolargin; Prolargin proteoglycan; Proline arginine rich end leucine rich repeat protein; Proline-arginine-rich end leucine-rich repeat protein; Proline/arginine rich end leucine rich repeat protein; SLRR2A. |
| Background | PRELP (proline/arginine-rich end leucine-rich repeat protein), also known as Prolargin, MST161, SLRR2A or MSTP161, is a 382 amino acid secreted protein that localizes to the extracellular matrix. Belonging to the Class II subfamily of the small leucine-rich proteoglycan (SLRP) family, PRELP contains twelve LRR (leucine-rich) repeats, which are motifs consisting of 20-29 residues that are present in numerous proteins with diverse functions and provide versatile structural framework for the formation of protein-protein interactions. Highly expressed in cartilage, basement membranes and developing bone, PRELP is considered a glycosaminoglycan (GAG)- and collagen-binding anchor protein that associates with the basement membrane heparan sulfate proteoglycan perlecan. PRELP acts as a linker between the extracellular matrix and the cell surface of proteoglycans and may be partially responsible for Hutchinson-Gilford progeria (HGP), an extremely rare genetic disorder that causes premature, rapid aging shortly after birth. |
| Application Dilution | |
| IHC-P | 1:500-1000 |
| IHC-F | 1:100-500 |
Frequently asked questions
Which applications is PRELP Polyclonal Antibody (bs-13707R) validated for, and at what dilution?
bs-13707R is validated for IHC-P (1:500-1000); IHC-F (1:100-500). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
How should bs-13707R be stored?
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise PRELP Polyclonal Antibody (bs-13707R)?
KLH conjugated synthetic peptide derived from human PRELP Immunogen range: 151-250/382.