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HLA-DR Polyclonal Antibody, PE Conjugated

Applications

  • WB
  • IF

Reactivity

  • Human
Overview
Catalog # bs-1198r-pe-100ul
Product Name HLA-DR Polyclonal Antibody, PE Conjugated
Applications WB, IF
Reactivity Human
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic peptide derived from human HLA-DRA
Immunogen Range 30-80/254
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 3122
Swiss Prot P01903
Subcellular location Extracellular
Synonyms MLRW; HLA-DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA-DRA
Background HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Application Dilution
WB 1:1000-5000
IF 1:500-2000