ACACA Polyclonal Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11912r |
| Product Name | ACACA Polyclonal Antibody |
| Applications |
WB
IHC-P
IF(IHC-P)
|
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human ACACA |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Synonyms | ACAC; ACACA; ACACA; ACACA_HUMAN; ACC alpha; ACC-alpha; ACC1; ACC1; ACCA; Acetyl Coenzyme A; Biotin carboxylase; ACACA_MOUSE; Acetyl Coenzyme A carboxylase alpha; ACACA_RAT. |
| Background | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC∫ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC∫ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N-terminus. |
| Application Dilution | |
| WB | |
| IHC-P | |
| IF(IHC-P) | |
Frequently asked questions
Which applications is ACACA Polyclonal Antibody (bs-11912R) validated for, and at what dilution?
bs-11912R is validated for WB, IHC-P, IF(IHC-P).
Which species does ACACA Polyclonal Antibody (bs-11912R) react with?
Tested reactivity: Human. Predicted reactivity (expected from sequence homology but not yet tested): Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit.
How should bs-11912R be stored?
Store at -20°C for 12 months. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise ACACA Polyclonal Antibody (bs-11912R)?
KLH conjugated synthetic peptide derived from human ACACA