ARNTL2/BMAL2 Polyclonal Antibody

Applications

  • WB
  • ELISA
  • IHC-P
  • IHC-F
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)
  • ICC

Predicted Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-11446R
Product Name ARNTL2/BMAL2 Polyclonal Antibody
Applications WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), ICC
Predicted Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ARNTL2
Immunogen Range 381-480/636
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 56938
Subcellular location Nucleus
Synonyms ARNT L2; ARNTL 2; ARNTL2; ARNTL2 protein; Aryl hydrocarbon receptor nuclear translocator like 2; Aryl hydrocarbon receptor nuclear translocator like protein 2; Aryl hydrocarbon receptor nuclear translocator-like 2; Basic helix loop helix PAS protein MOP9; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; BMA L2; BMAL 2; BMAL2; Brain and muscle ARNT like 2; Brain and muscle ARNT-like 2; CL; CYCLE like factor; CYCLE-like factor; Member of PAS protein 9; MGC124257; MGC149671; MGC149672; MGC158186; MOP 9; MOP9; PASD 9; PASD9; Transcription factor BMAL 2; Transcription factor BMAL2; wu:fj90c09; BMAL2_HUMAN.
Background BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500