| Overview |
| bs-1021R-PE |
| TLR4 Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Human, Mouse, Rat, Bovine, Cow |
| Dog, Sheep, Pig |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from rat TLR4 |
| 751-835/835 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 21898 |
| Q9QX05 |
| Cytoplasm, Cell membrane |
| Lps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4 |
| Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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