| Overview |
| bs-0988R-A488 |
| Transferrin receptor Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated |
| WB, FCM |
| Human, Mouse |
| Rat, Dog, Cow, Pig, Horse, Guinea Pig |
| Specifications |
| ALEXA FLUOR® 488 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Transferrin receptor |
| 621-720/760 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 7037 |
| P02786 |
| Cell membrane |
| T9; TR; TFR; p90; CD71; TFR1; TRFR; Transferrin receptor protein 1; TFRC |
| Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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