Overview |
bsm-70272M |
Synaptojanin 1 Antibody |
WB, IHC |
Specific for endogenous levels of the ~145 kDa synaptojanin I protein in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. |
Rat |
Specifications |
Unconjugated |
Mouse |
Recombinant protein from the C-terminal region of rat synaptojanin 1. |
Monoclonal |
5H1 |
IgG1 |
Lot Dependent |
Purified by Protein G. |
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
Target |
85238 |
Q62910 |
4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, Inositol 5' phosphatase (synaptojanin 1) antibody, Inositol 5' phosphatase antibody, INPP 5G antibody, INPP5G antibody, KIAA0910 antibody, PARK20 antibody, Polyphosphoinositide phosphatase antibody, Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol 145 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol-1 antibody, Synaptojanin antibody, Synaptojanin 1 antibody, Synaptojanin 1 polyphosphoinositide phosphatase antibody, Synaptojanin-1 antibody, Synaptojanin1 antibody, Synj 1 antibody, Synj1 antibody, SYNJ1_HUMAN antibody |
Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008). |
Application Dilution |
WB |
1:300-5000 |
IHC |
|