Overview |
bsm-54032R |
Alpha B Crystallin (1B12) Monoclonal Antibody |
WB, IHC-P, IF(IHC-P), IF(ICC) |
Human, Rat |
Specifications |
Unconjugated |
Rabbit |
Full length protein |
Monoclonal |
1B12 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
1410 |
P02511 |
Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, HspB5, CRYAB, CRYA2, HSPB5 |
Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into _, _ and _ families, and the _- and _-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. _-crystallins consist of three gene products, _A-, _B- and _C-crystallin, which are members of the small heat shock protein family (HSP 20). _-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, _-crystallins do not renature these proteins. Expression of _A-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human _B-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of _B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IF(IHC-P) |
1:50-200 |
IF(ICC) |
1:50-200 |